A new clinical trial by researchers at Baylor College of Medicine, in Houston, found that a combination of N-acetyl cysteine and glycine (GlyNAC) boosted glutathione—often referred to as the body’s master antioxidant—and improved or reversed many signs of aging. Twenty-four older adults and 12 young adults were studied. The older group was randomized to receive either GlyNAC or a placebo for 16 weeks, and the younger adults received GlyNAC for two weeks.

Participants were studied before, after two weeks and after 16 weeks of supplementation to assess glutathione concentrations, oxidative stress, mitochondrial fatty-acid oxidation, molecular regulators of energy metabolism, inflammation, endothelial function, insulin resistance, aging hallmarks, gait speed, muscle strength, walking (via a six-minute test), body composition and blood pressure. Supplementing with GlyNAC in the older adults was found to improve or correct these markers. Researchers concluded that this nutritional supplementation was a safe, well-tolerated and effective method for improving or reversing multiple, age-associated abnormalities to promote health in aging adults.