Pomegranate fruit has been widely used in traditional medicine, and a new, randomized, double-blind, placebo-controlled study published in the Journal of Clinical Medicine looked at the effects of taking pomegranate extract for a period of four weeks on different aspects of skin and gut health. Using facial imaging, researchers found the group that received the pomegranate extract had significant reductions in wrinkle severity and a decrease in the rate of forehead sebum excretion. They also found beneficial effects to the gut-skin axis, noting that participants in the pomegranate extract group had a higher abundance of Eggerthellaceae in the gut with accompanying wrinkle reduction. The scientists concluded that the skin benefits from pomegranate extract may be due to the potent antioxidant and anti-inflammatory properties of phytochemicals, as pomegranate contains more than 100 bioactive constituents.